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Patients with moderatecreatinine clearance30 to 50 mL/minand severecreatinine clearance.

Following oral administration of 1250 mg/m 2 capecitabine twice a day to cancer patients with varying degrees of renal impairmentpatients with moderatecreatinine clearance30 to 50 mL/minand severecreatinine clearance 80 mL/minSystemic exposure to 5DFUR was 42and 71greater in moderately and severely renal impaired patientsrespectivelythan in normal patientsSystemic exposure to capecitabine was about 25greater in both moderately and severely renal impaired patientssee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSWARNINGS AND PRECAUTIONSand Use In Specific Populations

Metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel when further anthracycline therapy is not indicatedegprior cumulative doses of 400mg/m 2 of doxorubicin or its equivalentsWith docetaxel craigslistglasgow. for metastatic breast cancer after failure of prior anthracycline-containing regimen.

Distributed byGenentech USAIncA Member of the Roche Group1 DNA WaySouth San FranciscoCA 94080-4990RevisedMar 2015.

The dose reduction schedule for docetaxel when used in combination with XELODA for the treatment of metastatic breast cancer is shown in Table 3.

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